Anime with orphan character? I'm looking for an anime with a good story that has either the main character or a prominent main character as an orphan (abandoned as a child counts, too). I like romance, but it doesn't have to be the focus of the story. I don't like moe, and I would prefer minimal to no ecchi. I like Fruits Basket, Gakuen Babysitters, and Love So Life, all of which touched on the idea. I also like the basic principles from Mayaoi Neko Overrun, but the anime was so dependent on sophomoric humor and bad dialogue that I got sick of it and stopped watching.
Fantastic Children - Thoma tries to help a girl he likes escape from an orphanage. A good sci-fi/fantasy anime with romance, but you have to be cool with not having any idea what's going on for the first half of the series. Black Butler (so obvious I hesitate to mention it.) Ciel Phantomhive has sold his soul in exchange for a demon butler to help him avenge the murder of his parents. Good story, fun, ghoulish characters, but no romance. Happy Lesson - A bit goofy, but it settles down after a few episodes. Chitose is an orphaned 17-year-old who lives on his own. He keeps getting in trouble, and five of his teachers decide that he needs a mom, so they all move in with him and adopt him...against his will. Not much romance. Midori Days - Seiji is another orphan delinquent living on his own, and all he wants is a girlfriend. One morning he wakes up to find that his hand has transformed into a cute girl who is in love with him. Romance, a bit moe, though. xxxHolic - Watanuki is an orphan who can see spirits. One day he is drawn to the door of Yuuko, a witch who can grant any wish, for a price. Soon he is working as her houseboy. Some romance (one-sided!) and a fun series. Spiral - An orphaned teen detective investigates the mysterious disappearance of his older brother. Just a little romance. Series is really good, but the ending is bad. (Must read manga to finish story.) My Santa - A boy named Santa who was born on Christmas is depressed because his parents are off working in another country and NEVER come home. A girl appears and claims she is a Santa-Claus-in-training, and it's her mission to make him happy. Minor ecchi.